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Where can I get more information?

The onset of symptoms generally occurs within several hours to a few days of concomitant use, but may occur later than that. Discontinue Demerol Injection if serotonin syndrome is suspected. This may not be a complete list of all interactions that may occur. Ask your health care provider if Detrol LA extended-release capsules may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine. QTdrugs List, AZCERT, Inc. Reserve concomitant prescribing of these drugs for use in patients for whom alternative treatment options are inadequate. Limit dosages and durations to the minimum required.

Side effects of detrol

Detrol LA extended-release capsules works best if it is taken at the same time each day. Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets. The stones can be brown or yellow, and smooth or rough. Avoid contact with people who have recently received live such as inhaled through the nose. FDA pregnancy category C. It is not known whether tolterodine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.

Important information

If you are taking this once daily and miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Opioids may also obscure the clinical course in a patient with a head injury. Avoid the use of Demerol Injection in patients with impaired consciousness or coma. Moderate. These medicines may cause some risk when taken together.

Indications and usage of detrol

Demerol Injection contains meperidine, a Schedule II controlled substance. Swallow this medication with the help of liquids. not crush or chew extended-release tablets. Doing so can release all of the drug at once, increasing the risk of side effects. Also, do not split the tablets unless they have a score line and your doctor or tells you to do so. Swallow the whole or split tablet without crushing or chewing. Adrenal insufficiency: Cases of adrenal insufficiency have been reported with opioid use, more often following greater than one month of use. Have your checked regularly while taking this medication. Learn how to monitor your own pressure at home, and share the results with your doctor.



See USP Controlled Room Temperature

For these reasons, FAERS case reports cannot be used to calculate incidence or estimates of risk for a particular product or compare risks between products. Alternatively, consider the use of non-opioid analgesics in these patients. How should I take tolterodine Detrol LA? Ask your pharmacist about the safe use of those products. Dosage should be adjusted according to the severity of the pain and the response of the patient. While subcutaneous administration is suitable for occasional use, intramuscular administration is preferred when repeated doses are required. If intravenous administration is required, dosage should be decreased and the injection made very slowly, preferably utilizing a diluted solution. Drowsiness and confusion can increase the risk of falling. What other drugs will affect tolterodine Detrol? These help to strengthen the pelvic floor after childbirth. They also help prevent stress incontinence. Best of all, you can do Kegels anytime, anywhere. Check the labels on all your medicines such as allergy or cough-and-cold products because they may contain ingredients that cause drowsiness. Ask your pharmacist about using those products safely. If your symptoms do not improve or if they become worse, check with your doctor. Demerol Injection exposes patients and other users to the risks of opioid addiction, abuse, and misuse, which can lead to overdose and death. Infants exposed to Demerol Injection through breast milk should be monitored for excess sedation and respiratory depression. Withdrawal symptoms can occur in breastfed infants when maternal administration of an opioid analgesic is stopped, or when breast-feeding is stopped. Demerol Injection, like other opioids, can be diverted for non-medical use into illicit channels of distribution. Careful record-keeping of prescribing information, including quantity, frequency, and renewal requests, as required by state and federal law, is strongly advised.



Detrol overdose

Your doctor will pass the scope through your bladder and ureter into your kidney. She uses a small basket to remove small stones. If the stones are larger, the doctor will pass a laser through the scope to break them up. Typically, you are able to go home on the same day. Drug addiction is a cluster of behavioral, cognitive, and physiological phenomena that develop after repeated substance use and includes a strong desire to take the drug, difficulties in controlling its use, persisting in its use despite harmful consequences, a higher priority given to drug use than to other activities and obligations, increased tolerance, and sometimes a physical withdrawal. Blurred vision; constipation; dizziness; drowsiness; dry eyes; dry mouth; headache; indigestion; stomach pain. The concomitant use of Demerol Injection and CYP3A4 or CYP2B6 inhibitors can increase the plasma concentration of meperidine, resulting in increased or prolonged opioid effects. It is readily soluble in water and has a neutral reaction and a slightly bitter taste. The solution is not decomposed by a short period of boiling. Drew BJ, Ackerman MJ, Funk M, Gibler WB, Kligfield P, Menon V, Philippides GJ, Roden DM, Zareba W. Prevention of torsade de pointes in hospital settings: a scientific statement from the American Heart Association and the American College of Cardiology Foundation. Opioids have been shown to have a variety of effects on components of the immune system in in vitro and animal models. The clinical significance of these findings is unknown. Overall, the effects of opioids appear to be modestly immunosuppressive. Consult your doctor for specific advice.



How should i take detrol

The opinions expressed in WebMD User-generated content areas like communities, reviews, ratings, or blogs are solely those of the User, who may or may not have medical or scientific training. These opinions do not represent the opinions of WebMD. User-generated content areas are not reviewed by a WebMD physician or any member of the WebMD editorial staff for accuracy, balance, objectivity, or any other reason except for compliance with our Terms and Conditions. What Are Warnings and Precautions for Tolterodine? Opioids are sought by drug abusers and people with addiction disorders and are subject to criminal diversion. Consider these risks when prescribing or dispensing Demerol Injection. Strategies to reduce these risks include prescribing the drug in the smallest appropriate quantity. This medication contains tolterodine. Do not take Detrol or Detrol LA if you are allergic to tolterodine or any ingredients contained in this drug. An extra patient leaflet is available with Detrol LA extended-release capsules. Talk to your pharmacist if you have questions about this information. It may rarely harm an unborn baby. Discuss the risks and benefits with your doctor. Infants born to mothers who have been using this medication for a long time may have problems. If concomitant use is necessary, consider dosage reduction of Demerol Injection until stable drug effects are achieved. Monitor patients for respiratory depression and sedation at frequent intervals. Meperidine produces respiratory depression by direct action on brain stem respiratory centers. The respiratory depression involves a reduction in the responsiveness of the brain stem respiratory centers to both increases in carbon dioxide tension and electrical stimulation. Allergic. Pruritus, urticaria, other skin rashes, wheal and flare over the vein with intravenous injection. Drink plenty of water: You should drink at least 64 ounces of water each day. Some of that liquid can be orange juice, lemonade, or limeade. Detrol LA extended-release capsules should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed. Concomitant use of Demerol Injection with CYP3A4 inducers or discontinuation of a CYP3A4 inhibitor could decrease meperidine plasma concentrations, decrease opioid efficacy or, possibly, lead to a withdrawal syndrome in a patient who had developed physical dependence to meperidine.



Consult your doctor before -feeding

If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip themissed dose and resume your usual dosing schedule. If concomitant use cimetidine and Demerol Injection is necessary, monitor patients for respiratory depression and sedation at frequent intervals. Acute overdose with Demerol Injection can be manifested by respiratory depression, somnolence progressing to stupor or coma, skeletal muscle flaccidity, cold and clammy skin, constricted pupils, and, in some cases, pulmonary edema, bradycardia, hypotension, partial or complete airway obstruction, atypical snoring, and death. Prolonged use of Demerol Injection during pregnancy can result in neonatal opioid withdrawal syndrome, which may be life-threatening if not recognized and treated, and requires management according to protocols developed by neonatology experts. The meperidine in Demerol Injection may increase the frequency of seizures in patients with seizure disorders, and may increase the risk of seizures occurring in other clinical settings associated with seizures. Monitor patients with a history of seizure disorders for worsened seizure control during Demerol Injection therapy. Because of these risks, reserve concomitant prescribing of these drugs for use in patients for whom alternative treatment options are inadequate. See USP Controlled Room Temperature.



Reviews for detrol

Taking flecainide with other agents that can affect your heart rhythm may increase your risk of an irregular heartbeat, which may be life-threatening. What happens if I overdose Detrol LA? WebMD User Reviews should not be considered as medical advice and are not a substitute for professional medical advice, diagnosis, or treatment. Never delay or disregard seeking professional medical advice from your physician or other qualified healthcare provider because of something you have read on WebMD. You should always speak with your doctor before you start, stop, or change any prescribed part of your care plan or treatment. WebMD understands that reading individual, real-life experiences may be a helpful health information resource but they are never a substitute for professional medical advice from a qualified healthcare provider. Read the Patient Information Leaflet if available from your pharmacist before you start using tolterodine and each time you get a refill. If you have any questions, ask your doctor or pharmacist. The major hazards of meperidine, as with other opioid analgesics, are respiratory depression and, to a lesser degree, circulatory depression; respiratory arrest, shock, and cardiac arrest have occurred. Other. Pain at injection site; local tissue irritation and induration following subcutaneous injection, particularly when repeated; antidiuretic effect. Tell your doctor if your condition persists or worsens. Do not start, stop, or change the dosage of any medicines without your doctor's approval. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.



QTdrugs List, AZCERT, Inc

Abuse of Demerol Injection poses a risk of overdose and death. The risk is increased with concurrent abuse of Demerol Injection with alcohol and other central nervous system depressants. Demerol Injection should not be used for treatment of chronic pain. It is not known whether tolterodine passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. Individually titrate Demerol Injection to a dose that provides adequate analgesia and minimizes adverse reactions. All medicines may cause side effects, but many people have no, or minor, side effects.



Detrol drug interactions

Accumulation of normeperidine as in chronic use or possibly following introduction of a concomitant CYP3A4 inducer presents as excitatory syndrome including hallucinations, tremors, muscle twitches, dilated pupils, hyperactive reflexes, and convulsions. Take Detrol LA extended-release capsules by mouth with or without food. Meperidine is metabolized through biotransformation. In vitro data show meperidine is metabolized to normeperidine in liver mainly by CYP3A4 and CYP2B6. Check with your pharmacist about how to dispose of unused medicine. If concomitant use of acyclovir and Demerol Injection is necessary, monitor patients for respiratory depression and sedation at frequent intervals. Caution is advised when using Detrol LA extended-release capsules in CHILDREN; they may be more sensitive to its effects, especially an increased risk for urinary tract infection and behavior or attention problems. Phenytoin: The hepatic metabolism of meperidine may be enhanced by phenytoin. Do not consider WebMD User-generated content as medical advice. Never delay or disregard seeking professional medical advice from your doctor or other qualified healthcare provider because of something you have read on WebMD. You should always speak with your doctor before you start, stop, or change any prescribed part of your care plan or treatment. WebMD understands that reading individual, real-life experiences can be a helpful resource but it is never a substitute for professional medical advice, diagnosis, or treatment from a qualified health care provider. If you think you may have a medical emergency, call your doctor or dial 911 immediately. It is not known whether this drug passes into milk. Consult your doctor before -feeding. If any of these effects persists or worsens, tell your doctor or promptly. Prolonged use of opioid analgesics during pregnancy for medical or nonmedical purposes can result in physical dependence in the neonate and neonatal opioid withdrawal syndrome shortly after birth. Meperidine causes a reduction in motility associated with an increase in smooth muscle tone in the antrum of the stomach duodenum. Digestion of food in the small intestine is delayed and propulsive contractions are decreased. Propulsive peristaltic waves in the colon are decreased, while tone may be increased to the point of spasm, resulting in constipation. Other opioid-induced effects may include a reduction in biliary and pancreatic secretions, spasm of sphincter of Oddi, and transient elevations in serum amylase. Flecainide can affect your heart's rhythm. Other drugs can have the same effect.



How should I take tolterodine Detrol LA?

Advise both patients and caregivers about the risks of respiratory depression and sedation when Demerol Injection is used with benzodiazepines or other CNS depressants including alcohol and illicit drugs. Advise patients not to drive or operate heavy machinery until the effects of concomitant use of the benzodiazepine or other CNS depressant have been determined. If concomitant use is warranted, carefully observe the patient, particularly during treatment initiation and dose adjustment. Discontinue Demerol Injection if serotonin syndrome is suspected. Americans, most of them women. There are several different types, causes, and treatments. This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. Parenteral drug abuse is commonly associated with transmission of infectious diseases such as hepatitis and HIV. Inform your doctor if your condition persists or worsens. This information should not be used to decide whether or not to take Detrol LA extended-release capsules or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Detrol LA extended-release capsules. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Detrol LA extended-release capsules. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using Detrol LA extended-release capsules. Side Effects List Detrol LA side effects by likelihood and severity. Store at room temperature away from light and moisture. not store in the bathroom. Keep all away from children and pets. Elderly patients aged 65 years or older may have increased sensitivity to meperidine. In general, use caution when selecting a dosage for an elderly patient, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function and of concomitant disease or other drug therapy. Prolonged use of Demerol Injection during pregnancy can result in withdrawal in the neonate. Neonatal opioid withdrawal syndrome, unlike opioid withdrawal syndrome in adults, may be life-threatening if not recognized and treated, and requires management according to protocols developed by neonatology experts. Observe newborns for signs of neonatal opioid withdrawal syndrome and manage accordingly. Serotonin syndrome: Cases of serotonin syndrome, a potentially life-threatening condition, have been reported during concomitant use of opioids with serotonergic drugs. Marked mydriasis rather than miosis may be seen due to hypoxia in overdose situations. Shock wave lithotripsy: This is the most common procedure for kidney stones in the United States. It uses shock waves, which can blast the stone into little pieces. Then, the smaller pieces can more easily be passed in your urine. Limit dosage and duration to the minimum required.



Detrol uses

The findings cannot be clearly attributed to maternal toxicity. Report prolonged or to your doctor. Low levels of potassium or magnesium in the blood may also increase your risk of QT prolongation. Meperidine produces peripheral vasodilation which may result in orthostatic hypotension or syncope. Consult your pharmacist for further advice. What happens if I miss a dose Detrol? When a patient who has been taking Demerol Injection regularly and may be physically dependent no longer requires therapy with Demerol Injection, taper the dose gradually, by 25% to 50% every 2 to 4 days, while monitoring carefully for signs and symptoms of withdrawal. If the patient develops these signs or symptoms, raise the dose to the previous level and taper more slowly, either by increasing the interval between decreases, decreasing the amount of change in dose, or both. Mental or physical problems such as or prevent you from getting to the bathroom in time.



DEMEROL is not a trademark of Hospira

Food and Drug Administration. WebMD does not endorse any specific product, service, or treatment. What is the most important information I should know about tolterodine Detrol LA? Detrol LA extended-release capsules may cause drowsiness, dizziness, or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use Detrol LA extended-release capsules with caution. In case of overdose, priorities are the reestablishment of a patent and protected airway and institution of assisted or controlled ventilation, if needed. Employ other supportive measures including oxygen and vasopressors in the management of circulatory shock and pulmonary edema as indicated. Cardiac arrest or arrhythmias will require advanced life-support techniques. Using corticosteroid for a long time can make it more difficult for your body to respond to physical stress. This may occur within the recommended dosage range. Let your doctor know right away if you notice an irregular heartbeat or have any dizziness or fainting episodes. Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.



How should i store detrol

Remember that your doctor has prescribed this because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication not have serious side effects. Catheter. Some people use a catheter to make sure their bladder is emptied. It's a thin plastic tube that you insert in your urethra. A doctor or nurse can teach you how to insert it for yourself. If concomitant use is necessary, consider increasing the Demerol Injection dosage until stable drug effects are achieved. Monitor for signs of opioid withdrawal. If a CYP3A4 or CYP2B6 inducer is discontinued, consider Demerol Injection dosage reduction and monitor for signs of respiratory depression. If you have any questions about Detrol LA extended-release capsules, please talk with your doctor, pharmacist, or other health care provider. The minimum effective analgesic concentration will vary widely among patients, especially among patients who have been previously treated with potent agonist opioids. Studies in animals to evaluate the mutagenic potential of meperidine have not been conducted. The opioid antagonists, naloxone or nalmefene, are specific antidotes to respiratory depression resulting from opioid overdose. For clinically significant respiratory or circulatory depression secondary to meperidine overdose, administer an opioid antagonist. Opioid antagonists should not be administered in the absence of clinically significant respiratory or circulatory depression secondary to meperidine overdose.



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Detrol dosing information


How should I take tolterodine Detrol?

Meperidine appears in the milk of nursing mothers receiving the drug. The developmental and health benefits of breastfeeding should be considered along with the mother's clinical need for Demerol Injection and any potential adverse effects on the breastfed infant from Demerol Injection or from the underlying maternal condition. UpToDate: "Nutrition and Dietary Interventions in Adults with Inflammatory Bowel Disease. Concomitant use of Demerol Injection with monoamine oxidase MAO inhibitors can result in coma, severe respiratory depression, cyanosis, and hypotension. First, she will get a medical history and examine you.

Common side effects of detrol

To prevent needle-stick injuries, needles should not be recapped, purposely bent, or broken by hand. Both tolerance and physical dependence can develop during chronic opioid therapy. Tolerance is the need for increasing doses of opioids to maintain a defined effect such as analgesia in the absence of disease progression or other external factors. Tolerance may occur to both the desired and undesired effects of drugs, and may develop at different rates for different effects. This medication is used to treat an overactive bladder. By relaxing the muscles in the bladder, tolterodine improves your ability to control your urination. It helps to reduce leaking of urine, feelings of needing to urinate right away, and frequent trips to the bathroom. This medication belongs to the class of drugs known as antispasmodics.

Before taking detrol

Proper assessment of the patient, proper prescribing practices, periodic re-evaluation of therapy, and proper dispensing and storage are appropriate measures that help to limit abuse of opioid drugs. Check the Rx Outreach website for the exact price and most current medication list. DEMEROL is not a trademark of Hospira. What is tolterodine Detrol?

What is tolterodine Detrol LA?

Discuss the risks and benefits with your doctor. Demerol Injection may cause severe hypotension including orthostatic hypotension and syncope in ambulatory patients. The half-life of meperidine is 2 to 5 hours, and the half-life of normeperidine is 15 to 30 hours. The concomitant use of Demerol Injection with all cytochrome P450 3A4 inhibitors may result in an increase in meperidine plasma concentrations, which could increase or prolong adverse reactions and may cause potentially fatal respiratory depression. In addition, discontinuation of a concomitantly used cytochrome P450 3A4 inducer may result in an increase in meperidine plasma concentration.

This drug may make you dizzy or drowsy or cause blurred vision. Do not drive, use machinery, or do any activity that requires alertness or clear vision until you are sure you can perform such activities safely. Limit alcoholic beverages. This program provides uninsured patients with savings on their prescriptions at the pharmacy. Cases of serotonin syndrome, a potentially life-threatening condition, have been reported during concomitant use of Demerol Injection with serotonergic drugs. In an individual physically dependent on opioids, administration of the recommended usual dosage of the antagonist will precipitate an acute withdrawal syndrome. The severity of the withdrawal symptoms experienced will depend on the degree of physical dependence and the dose of the antagonist administered. If a decision is made to treat serious respiratory depression in the physically dependent patient, administration of the antagonist should be begun with care and by titration with smaller than usual doses of the antagonist.

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